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KMID : 0545120150250060946
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Journal of Microbiology and Biotechnology
2015 Volume.25 No. 6 p.946 ~ p.950
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Anti-Mycobacterial Activity of Tamoxifen Against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis
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Jang Woong-Sik
Kim Su-Kyung
Biswajit Podder
Md. Anirban Jyoti
Nam Kung-Woo
Lee Byung-Eui
Song Ho-Yeon
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Abstract
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Recently, it has become a struggle to treat tuberculosis with the current commercial antituberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We evaluated here the antimycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drugsensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had antituberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 μg/ml) as well as drugresistant strains (MIC, 6.25 to 12.5 μg/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.
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KEYWORD
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Mycobacterium tuberculosis, Tamoxifen, Intracellular killing, MDR, XDR
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